February 5, 2018 at 9:31 pm #5288
*BIOCHEMISTRY OF CANCER*
Cancer is simply the gain of oncogenes and the loss of
tumor suppressor genes . Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Activated oncogenes result form different types of mutations including point mutations, chromosomal translocations, promoter translocations, and amplifications. Point mutations increase proteins’ activity and prevent it from being turned off. Chromosomal translocations encode fusion proteins that are hyperactivated or inappropriately regulated or localized. Promoter translocations drive abnormally high levels of expression. Amplifications increase the copy number and expression of a gene. Tumor suppressor genes (TSG) are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system. Tumor suppressor genes can be inactivated by missense mutations that decrease the protein’s activity, deletions, frameshifts, and promoter methylation.Thoughtful Comments: 0.
February 6, 2018 at 2:12 pm #5307
Welcome! How will a layman understand this write up and what is the benefit of this information help the ordinary person to deal with cancer? I do not mean to be rude but I believe the goal of each writing should be to raise questions (direct or rhetorical) about existing situations and maybe suggest possible solutions for prevention or cure.
In a nation with so many people facing serious health problems in the face of leaner purses, any health knowledge we can impart is invaluable. It should thus be conveyed in a manner that will help the reader to understand and arrive at a better point after the reading experience.Thoughtful Comments: 10. 10 (helpful)
February 6, 2018 at 5:25 pm #5318
I really appreciate your sincere concern towards the post. Your suggestions will be taken into effective consideration in subsequent posts. Thanks a mill.!Thoughtful Comments: 0.
February 6, 2018 at 6:38 pm #5323
You’re welcome. Keep up the good work.Thoughtful Comments: 0.
February 6, 2018 at 7:54 pm #5325
talklessthinkmoreParticipantFiltered Thoughts Points: 1180
Wow! I love what I’m reading here. Femi making decent observation about someone’s writing while Tobyphd takes the comments in good fate. Thumbs up to both of you for your matured conversation.Thoughtful Comments: 0.
February 7, 2018 at 5:41 am #5333
February 7, 2018 at 10:23 am #5354
That is how it should be, my friend. Why did I choose to use my real name on this platform? Because I believe that ‘omi leniyan.’ The bonds we forge here can see us joining hands to change our society for better. It costs nothing to give suggestions with humility and in good faith just as it costs nothing to be humble and gracious in responding to comments, even the ones we don’t really respect.
Thoughtful Comments: 10. 10 (insightful)
- This reply was modified 9 months, 1 week ago by Femi Onileagbon.
February 7, 2018 at 11:19 pm #5397
You have just spoken well.!
More greace to your elbow sir.Thoughtful Comments: 0.
February 12, 2018 at 5:09 pm #5623
ValentinefridayParticipantFiltered Thoughts Points:
Very well presented case although as earlier observed, laymen might not grasp the great implications of what was typed, I think an explanation of cancer as a disease is needed in the country, with emphasis on TSGs and oncogene activation, sadly the educational climate doesn’t encourage expansive explanations as regards to the aetiology of cancer, nowadays it seems protein expression as regards to oncogene is a leading problem and early detection as in the case of the new method of detecting with the markers in the blood is crucial to the survival of affected people, nice work but as always “it’s hard to explain Bch without constructing imaginations”.Thoughtful Comments: 0.
February 14, 2018 at 1:15 am #5663
IykeParticipantFiltered Thoughts Points: 240
I read this write up and understood where you are pointing to.
The truth is that the average man I. The street will fail to understand this. Apologies! It’s too ambiguous.
While writing again try and use simple grammar for better understanding.
I don’t mean to turn your efforts down. I only meant to be frank with you.. Thanks for your understanding.Thoughtful Comments: 0.
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